Article

Comparative Genome-Wide Dna Methylation Analysis In Myocardial Tissue From Donors With And Without Down Syndrome

2020-07-15

Abstract excerpt

Down syndrome (DS, trisomy 21) is the most common major chromosomal aneuploidy compatible with life. The additional whole or partial copy of chromosome 21 results in genome-wide imbalances that drive the complex pathobiology of DS. Differential DNA methylation in the context of trisomy 21 may contribute to the variable architecture of the DS phenotype. The goal of this study was to examine the genomic DNA methylat...

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Literature Corpus work: 4695e257-1f9f-56a2-a968-65d759c78b0c
DOI: 10.1101/2020.07.15.203075

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