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Article

Altered LINE-1 Methylation in Mothers of Children with Down Syndrome.

PloS one - 1 Jan 2015

Božović Ivana Babić, Stanković Aleksandra, Živković Maja, Vraneković Jadranka, Kapović Miljenko, Brajenović-Milić Bojana

Abstract excerpt

Down syndrome (DS, also known as trisomy 21) most often results from chromosomal nondisjunction during oogenesis. Numerous studies sustain a causal link between global DNA hypomethylation and genetic instability. It has been suggested that DNA hypomethylation might affect the structure and dynamics of chromatin regions that are critical for chromosome stability and segregation, thus favouring chromosomal...

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Identifiers

PMID: 26017139
DOI: 10.1371/journal.pone.0127423
PMCID: PMC4446367

Genes

MTHFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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