DNA Methylation Profiling of Uniparental Disomy Subjects Provides a Map of Parental Epigenetic Bias in the Human Genome.

doi:10.1016/j.ajhg.2016.06.032

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Article

DNA Methylation Profiling of Uniparental Disomy Subjects Provides a Map of Parental Epigenetic Bias in the Human Genome.

American journal of human genetics - 1 Sept 2016

Joshi Ricky S, Garg Paras, Zaitlen Noah, Lappalainen Tuuli, Watson Corey T, Azam Nidha, Ho Daniel, Li Xin, Antonarakis Stylianos E, Brunner Han G, Buiting Karin, Cheung Sau Wai, Coffee Bradford, Eggermann Thomas, Francis David, Geraedts Joep P, Gimelli Giorgio, Jacobson Samuel G, Le Caignec Cedric, de Leeuw Nicole, Liehr Thomas, Mackay Deborah J, Montgomery Stephen B, Pagnamenta Alistair T, Papenhausen Peter, Robinson David O, Ruivenkamp Claudia, Schwartz Charles, Steiner Bernhard, Stevenson David A, Surti Urvashi, Wassink Thomas, Sharp Andrew J

Abstract excerpt

Genomic imprinting is a mechanism in which gene expression varies depending on parental origin. Imprinting occurs through differential epigenetic marks on the two parental alleles, with most imprinted loci marked by the presence of differentially methylated regions (DMRs). To identify sites of parental epigenetic bias, here we have profiled DNA methylation patterns in a cohort of 57 individuals with uniparental...

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PMID: 27569549
DOI: 10.1016/j.ajhg.2016.06.032
PMCID: PMC5011056

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TUBGCP5

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