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Article

Induction of intestinalization in human esophageal keratinocytes is a multistep process

8 Oct 2008

Abstract excerpt

Barrett's esophagus (BE) is the replacement of normal squamous esophageal mucosa with an intestinalized columnar epithelium. The molecular mechanisms underlying its development are not understood. Cdx2 is an intestine-specific transcription factor that is ectopically expressed in BE, but its role in this process is unclear. Herein, we describe a novel cell culture model for BE. Retroviral-mediated Cdx2 expression...

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Share to Digestive system and related health
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PMID: 18845559
DOI: 10.1093/carcin/bgn227

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