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Article

CDX1 confers intestinal phenotype on gastric epithelial cells via induction of stemness-associated reprogramming factors SALL4 and KLF5.

Proceedings of the National Academy of Sciences of the United States of America - 11 Dec 2012

Fujii Yumiko, Yoshihashi Kyoko, Suzuki Hidekazu, Tsutsumi Shuichi, Mutoh Hiroyuki, Maeda Shin, Yamagata Yukinori, Seto Yasuyuki, Aburatani Hiroyuki, Hatakeyama Masanori

Abstract excerpt

Intestinal metaplasia of the stomach, a mucosal change characterized by the conversion of gastric epithelium into an intestinal phenotype, is a precancerous lesion from which intestinal-type gastric adenocarcinoma arises. Chronic infection with Helicobacter pylori is a major cause of gastric inte...

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Source

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Identifiers

PMID: 23112162
DOI: 10.1073/pnas.1208651109
PMCID: PMC3528493

Genes

CDX1
KLF5
SALL4
CDX2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23112162-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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