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Article

Altered oncomodules underlie chromatin regulatory factors driver mutations.

Oncotarget - 24 May 2016

Frigola Joan, Iturbide Ane, Lopez-Bigas Nuria, Peiro Sandra, Gonzalez-Perez Abel

Abstract excerpt

Chromatin regulatory factors (CRFs), are known to be involved in tumorigenesis in several cancer types. Nevertheless, the molecular mechanisms through which driver alterations of CRFs cause tumorigenesis remain unknown. Here, we developed a CRFs Oncomodules Discovery approach, which mines several sources of cancer genomics and perturbaomics data. The approach prioritizes sets of genes significantly miss-regulated...

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Identifiers

PMID: 27095575
DOI: 10.18632/oncotarget.8752
PMCID: PMC5058714

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Source receipt: pubmed, retrieved 7 Sept 2026.

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