Article

Genetic aberrations in chromatin factors are pervasive, mutually exclusive, associated with a high mutational burden and improved response to checkpoint immunotherapy in cancer

2019-12-03

Abstract excerpt

In recent years, it has been shown that many of the pervasive genetic defects in cancer occur in chromatin modifiers. Herein, we analyzed the distribution and mutual relationships of genetic aberrations in relevant chromatin modifiers in tens of thousands of publicly available cancer datasets. We observed that in general, they are mutually exclusive, and their prevalence is higher in some types of cancers compared...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e23c5747-cf28-5e72-b8ed-8b61ae939998
DOI: 10.1101/861823

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Genetic aberrations in chromatin factors are pervasive, mutually exclusive, associated with a high mutational burden and improved response to checkpoint immunotherapy in cancerDOI 10.1101/861823Read

Genetic aberrations in chromatin factors are pervasive, mutually exclusive, associated with a high mutational burden and improved response to checkpoint immunotherapy in cancerSemantic proximity Read

Tumors with mutations in chromatin regulators are associated with higher mutational burden and improved response to checkpoint immunotherapySemantic proximity Read

Tumors with mutations in chromatin regulators are associated with higher mutational burden and improved response to checkpoint immunotherapy.Semantic proximity Read

Tumors with mutations in chromatin regulators are associated with higher mutational burden and improved response to checkpoint immunotherapySemantic proximity Read

Mutational landscape and significance across 12 major cancer types.Semantic proximity Read

Epigenomic Consequences of Coding and Noncoding Driver Mutations.Semantic proximity Read

Chromatin signatures of cancer.Semantic proximity Read

Mutations in regulators of the epigenome and their connections to global chromatin patterns in cancer.Semantic proximity Read

Chromatin Mechanisms Driving Cancer.Semantic proximity Read

Motif Disruption Domains Lead To Cancer Gene Expression RewiringSemantic proximity Read

Topography of mutational signatures in human cancer.Semantic proximity Read

Driver and passenger mutations in cancer.Semantic proximity Read