Article

Tumors with mutations in chromatin regulators are associated with higher mutational burden and improved response to checkpoint immunotherapy

2025-10-31

Abstract excerpt

<title>Abstract</title> <p>In recent years, it has been demonstrated that many of the pervasive genetic defects throughout cancerogenesis occur in genes encoding chromatin regulators (CRs). We analyzed the distribution and characteristics of well-studied CRs across tens of thousands of tumor samples. Our analysis revealed that tumors with mutations in CRs are associated with high tumor mutational burden (TMB). Th...

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Literature Corpus work: 5ad74b18-0133-55f6-b2f9-ad8ab251af00
DOI: 10.21203/rs.3.rs-6202098/v1

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