Article
Candidate Cancer Driver Mutations in Distal Regulatory Elements and Long-Range Chromatin Interaction Networks.
Molecular cell - 19 Mar 2020
Zhu Helen, Uusküla-Reimand Liis, Isaev Keren, Wadi Lina, Alizada Azad, Shuai Shimin, Huang Vincent, Aduluso-Nwaobasi Dike, Paczkowska Marta, Abd-Rabbo Diala, Ocsenas Oliver, Liang Minggao, Thompson J Drew, Li Yao, Ruan Luyao, Krassowski Michal, Dzneladze Irakli, Simpson Jared T, Lupien Mathieu, Stein Lincoln D, Boutros Paul C, Wilson Michael D, Reimand Jüri
Abstract excerpt
A comprehensive catalog of cancer driver mutations is essential for understanding tumorigenesis and developing therapies. Exome-sequencing studies have mapped many protein-coding drivers, yet few non-coding drivers are known because genome-wide discovery is challenging. We developed a driver discovery method, ActiveDriverWGS, and analyzed 120,788 cis-regulatory modules (CRMs) across 1,844 whole tumor genomes from...
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