Article

Tumors with mutations in chromatin regulators are associated with higher mutational burden and improved response to checkpoint immunotherapy

2024-10-16

Abstract excerpt

In recent years, it has been demonstrated that many of the pervasive genetic defects throughout cancerogenesis occur in genes encoding chromatin regulators (CRs). We analyzed the distribution and characteristics of well-studied CRs across tens of thousands of tumor samples. Our analysis revealed that tumors with mutations in CRs are associated with high tumor mutational burden (TMB). The co-occurrence of mutations...

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Literature Corpus work: 6e70cec5-a9c5-5c20-8e13-c958feb16909
DOI: 10.1101/2024.10.15.24315153

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