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Decoding functional impact of epigenetic regulator mutations on ligand-receptor interaction perturbations for evaluation of cancer immunotherapy.

Journal of cellular and molecular medicine - 1 Sept 2024

Shi Aiai, Lin Chaohuan, Lyu Jie

Abstract excerpt

Cellular crosstalk mediated by ligand-receptor interactions largely complicates the tumour ecosystem, resulting in heterogeneous tumour microenvironments that affect immune response and clinical benefits from immunotherapy. Epigenetic mechanisms are pivotal to expression changes of immune-related genes and can modulate the anti-tumour immune response. However, the functional consequences of disrupted epigenetic...

Topics

Humans
Immunotherapy
Mutation
Neoplasms
Epigenesis, Genetic
Tumor Microenvironment
Gene Expression Regulation, Neoplastic
B7-H1 Antigen
Ligands
Programmed Cell Death 1 Receptor
Prognosis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Computational Biology

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Identifiers

PMID: 39323009
DOI: 10.1111/jcmm.70009
PMCID: PMC11424496

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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