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Article

A workflow to study mechanistic indicators for driver gene prediction with Moonlight.

Briefings in bioinformatics - 20 Sept 2023

Nourbakhsh Mona, Saksager Astrid, Tom Nikola, Chen Xi Steven, Colaprico Antonio, Olsen Catharina, Tiberti Matteo, Papaleo Elena

Abstract excerpt

Prediction of driver genes (tumor suppressors and oncogenes) is an essential step in understanding cancer development and discovering potential novel treatments. We recently proposed Moonlight as a bioinformatics framework to predict driver genes and analyze them in a system-biology-oriented manner based on -omics integration. Moonlight uses gene expression as a primary data source and combines it with patterns...

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Identifiers

PMID: 37551622
DOI: 10.1093/bib/bbad274
PMCID: PMC10516357

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