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Article

Multi-omics analysis of HLTF context-dependent regulation across TCGA cohorts revealed its potential as new biomarker in tumour.

Mammalian genome : official journal of the International Mammalian Genome Society - 24 Jul 2026

Canevotti Alessia, Tursunović Marija, Tigani Wendalina, Pesole Graziano, Chiara Matteo, De March Matteo

Abstract excerpt

The SNF2-family Helicase-Like Transcription Factor (HLTF) has been implicated in tumorigenesis, with evidence suggesting both tumour-suppressive and oncogenic functions. To clarify the nature of this increasingly emerging double function, we analysed the full HLTF's alterome across TCGA cohorts combining first gene expression with genomic and epigenomic layers of de-regulation, and investigating further their...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42498904
DOI: 10.1007/s00335-026-10257-w
PMCID: PMC13400721

Genes

HLTF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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