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Article

Hydrogen-bonded water molecules in the M2 channel of the influenza A virus guide the binding preferences of ammonium-based inhibitors.

The journal of physical chemistry. B - 22 Jan 2015

Gianti Eleonora, Carnevale Vincenzo, DeGrado William F, Klein Michael L, Fiorin Giacomo

Abstract excerpt

The tetrameric M2 proton channel of influenza A virus is an integral membrane protein responsible for the acidification of the viral interior. Drugs such as amantadine target the transmembrane region of wild type M2 by acting as pore blockers. However, a number of mutations affecting this domain confer drug resistance, prompting the need for alternative inhibitors. The availability of high-resolution structures...

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Identifiers

PMID: 25353315
DOI: 10.1021/jp506807y
PMCID: PMC4386636

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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