Article
A Study of the Activity of Adamantyl Amines against Mutant Influenza A M2 Channels Identified a Polycyclic Cage Amine Triple Blocker, Explored by Molecular Dynamics Simulations and Solid-State NMR.
ChemMedChem - 15 Aug 2023
Stampolaki Μarianna, Hoffmann Anja, Tekwani Kumar, Georgiou Kyriakos, Tzitzoglaki Christina, Ma Chunlong, Becker Stefan, Schmerer Patrick, Döring Kristin, Stylianakis Ioannis, Turcu Andreea L, Wang Jun, Vázquez Santiago, Andreas Loren B, Schmidtke Michaela, Kolocouris Antonios
Abstract excerpt
We compared the anti-influenza potencies of 57 adamantyl amines and analogs against influenza A virus with serine-31 M2 proton channel, usually termed as WT M2 channel, which is amantadine sensitive. We also tested a subset of these compounds against viruses with the amantadine-resistant L26F, V27A, A30T, G34E M2 mutant channels. Four compounds inhibited WT M2 virus in vitro with mid-nanomolar potency, with 27...
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