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Article

Drug-induced conformational and dynamical changes of the S31N mutant of the influenza M2 proton channel investigated by solid-state NMR.

Journal of the American Chemical Society - 3 Jul 2013

Williams Jonathan K, Tietze Daniel, Wang Jun, Wu Yibing, DeGrado William F, Hong Mei

Abstract excerpt

The M2 protein of influenza A viruses forms a tetrameric proton channel that is targeted by the amantadine class of antiviral drugs. A S31N mutation in the transmembrane (TM) domain of the protein has caused widespread amantadine resistance in most of the currently circulating flu viruses. Recently, a new family of compounds based on amantadine- and aryl-substituted isoxazole were discovered to inhibit the S31N...

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Identifiers

PMID: 23758317
DOI: 10.1021/ja4041412
PMCID: PMC4004037

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