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Article

Na+, HCO3--cotransporter NBCn1 increases pHi gradients, filopodia, and migration of smooth muscle cells and promotes arterial remodelling.

Cardiovascular research - 1 Aug 2016

Boedtkjer Ebbe, Bentzon Jacob F, Dam Vibeke S, Aalkjaer Christian

Abstract excerpt

AIMS: Arterial remodelling can cause luminal narrowing and obstruct blood flow. We tested the hypothesis that cellular acid-base transport facilitates proliferation and migration of vascular smooth muscle cells (VSMCs) and enhances remodelling of conduit arteries. METHODS AND RESULTS: [Formula: see text]-cotransport via NBCn1 (Slc4a7) mediates net acid extrusion and controls steady-state intracellular pH (pHi) in...

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PMID: 27076468
DOI: 10.1093/cvr/cvw079

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