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Article

A mechanism for the activation of the Na/H exchanger NHE-1 by cytoplasmic acidification and mitogens.

EMBO reports - 1 Jan 2004

Lacroix Jérôme, Poët Mallorie, Maehrel Céline, Counillon Laurent

Abstract excerpt

Eukaryotic cells constantly have to fight against internal acidification. In mammals, this task is mainly performed by the ubiquitously expressed electroneutral Na(+)/H(+) exchanger NHE-1, which activates in a cooperative manner when cells become acidic. Despite its biological importance, the mechanism of this activation is still poorly understood, the most commonly accepted hypothesis being the existence of a...

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Identifiers

PMID: 14710192
DOI: 10.1038/sj.embor.7400035
PMCID: PMC1298952

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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