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Article

Increased NBCn1 expression, Na+/HCO3- co-transport and intracellular pH in human vascular smooth muscle cells with a risk allele for hypertension.

Human molecular genetics - 1 Mar 2017

Ng Fu Liang, Boedtkjer Ebbe, Witkowska Kate, Ren Meixia, Zhang Ruoxin, Tucker Arthur, Aalkjær Christian, Caulfield Mark J, Ye Shu

Abstract excerpt

Genome-wide association studies have revealed an association between variation at the SLC4A7 locus and blood pressure. SLC4A7 encodes the electroneutral Na+/HCO3- co-transporter NBCn1 which regulates intracellular pH (pHi). We conducted a functional study of variants at this locus in primary cultures of vascular smooth muscle and endothelial cells. In both cell types, we found genotype-dependent differences for...

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Identifiers

PMID: 28087731
DOI: 10.1093/hmg/ddx015
PMCID: PMC5409084

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