Article
Action Potential Shortening and Impairment of Cardiac Function by Ablation of Slc26a6.
Circulation. Arrhythmia and electrophysiology - 1 Oct 2017
Sirish Padmini, Ledford Hannah A, Timofeyev Valeriy, Thai Phung N, Ren Lu, Kim Hyo Jeong, Park Seojin, Lee Jeong Han, Dai Gu, Moshref Maryam, Sihn Choong-Ryoul, Chen Wei Chun, Timofeyeva Maria Valeryevna, Jian Zhong, Shimkunas Rafael, Izu Leighton T, Chiamvimonvat Nipavan, Chen-Izu Ye, Yamoah Ebenezer N, Zhang Xiao-Dong
Abstract excerpt
BACKGROUND: Intracellular pH (pHi) is critical to cardiac excitation and contraction; uncompensated changes in pHi impair cardiac function and trigger arrhythmia. Several ion transporters participate in cardiac pHi regulation. Our previous studies identified several isoforms of a solute carrier Slc26a6 to be highly expressed in cardiomyocytes. We show that Slc26a6 mediates electrogenic Cl-/HCO3- exchange...
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