Article
Increased Epithelial Sodium Channel Activity Contributes to Hypertension Caused by Na+-HCO3- Cotransporter Electrogenic 2 Deficiency.
Hypertension (Dallas, Tex. : 1979) - 1 Jul 2015
Wen Donghai, Yuan Yang, Warner Paige C, Wang Bangchen, Cornelius Ryan J, Wang-France Jun, Li Huaqing, Boettger Thomas, Sansom Steven C
Abstract excerpt
The gene SLC4A5 encodes the Na(+)-HCO3 (-) cotransporter electrogenic 2, which is located in the distal nephron. Genetically deleting Na(+)-HCO3 (-) cotransporter electrogenic 2 (knockout) causes Na(+)-retention and hypertension, a phenotype that is diminished with alkali loading. We performed experiments with acid-loaded mice and determined whether overactive epithelial Na(+) channels (ENaC) or the Na(+)-Cl(-)...
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