Article

Inhibition of the sodium-dependent HCO 3 - transporter SLC4A4, produces a cystic fibrosis-like airway disease phenotype

2021-12-16

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<h4>ABSTRACT</h4> Bicarbonate secretion is a fundamental process involved in maintaining acid-base homeostasis. Disruption of bicarbonate entry into airway lumen, as has been observed in cystic fibrosis, produces several defects in lung function due to thick mucus accumulation. Bicarbonate is critical for correct mucin deployment and there is increasing interest in understanding its role in airway physiology, par...

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Literature Corpus work: 50a57dce-1d6c-50ff-9507-27bcfbc20397
DOI: 10.1101/2021.12.14.472535

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Inhibition of the sodium-dependent HCO <sub>3</sub> <sup>-</sup> transporter SLC4A4, produces a cystic fibrosis-like airway disease phenotype

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