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Article

Acid-base effects of combined renal deletion of NBCe1-A and NBCe1-B.

American journal of physiology. Renal physiology - 1 Feb 2022

Lee Hyun-Wook, Verlander Jill W, Shull Gary E, Harris Autumn N, Weiner I David

Abstract excerpt

The molecular mechanisms regulating ammonia metabolism are fundamental to acid-base homeostasis. Deletion of the A splice variant of Na+-bicarbonate cotransporter, electrogenic, isoform 1 (NBCe1-A) partially blocks the effect of acidosis to increase urinary ammonia excretion, and this appears to involve the dysregulated expression of ammoniagenic enzymes in the proximal tubule (PT) in the cortex but not in the...

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Source

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Identifiers

PMID: 35001662
DOI: 10.1152/ajprenal.00358.2021
PMCID: PMC8836747

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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