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Article

Resistance to cardiomyocyte hypertrophy in ae3-/- mice, deficient in the AE3 Cl-/HCO3- exchanger.

BMC cardiovascular disorders - 21 Jul 2014

Sowah Daniel, Brown Brittany F, Quon Anita, Alvarez Bernardo V, Casey Joseph R

Abstract excerpt

BACKGROUND: Cardiac hypertrophy is central to the etiology of heart failure. Understanding the molecular pathways promoting cardiac hypertrophy may identify new targets for therapeutic intervention. Sodium-proton exchanger (NHE1) activity and expression levels in the heart are elevated in many models of hypertrophy through protein kinase C (PKC)/MAPK/ERK/p90RSK pathway stimulation. Sustained NHE1 activity,...

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Identifiers

PMID: 25047106
DOI: 10.1186/1471-2261-14-89
PMCID: PMC4120010

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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