Article
Platelet-derived growth factor maintains stored calcium through a nonclustering Orai1 mechanism but evokes clustering if the endoplasmic reticulum is stressed by store depletion.
Circulation research - 22 Jun 2012
McKeown Lynn, Moss Nicholas K, Turner Paul, Li Jing, Heath Nikki, Burke Dermot, O'Regan David, Gilthorpe Mark S, Porter Karen E, Beech David J
Abstract excerpt
RATIONALE: Calcium entry through Orai1 channels drives vascular smooth muscle cell migration and neointimal hyperplasia. The channels are activated by the important growth factor platelet-derived growth factor (PDGF). Channel activation is suggested to depend on store depletion, which redistributes and clusters stromal interaction molecule 1 (STIM1), which then coclusters and activates Orai1. OBJECTIVE: To...
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