Article
Integrated analysis of genome-wide DNA methylation and gene expression profiles in molecular subtypes of breast cancer.
Nucleic acids research - 1 Oct 2013
Rhee Je-Keun, Kim Kwangsoo, Chae Heejoon, Evans Jared, Yan Pearlly, Zhang Byoung-Tak, Gray Joe, Spellman Paul, Huang Tim H-M, Nephew Kenneth P, Kim Sun
Abstract excerpt
Aberrant DNA methylation of CpG islands, CpG island shores and first exons is known to play a key role in the altered gene expression patterns in all human cancers. To date, a systematic study on the effect of DNA methylation on gene expression using high resolution data has not been reported. In this study, we conducted an integrated analysis of MethylCap-sequencing data and Affymetrix gene expression microarray...
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