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Mosquito Passage Dramatically Changes var Gene Expression in Controlled Human Plasmodium falciparum Infections

12 Apr 2016

Abstract excerpt

Virulence of the most deadly malaria parasite Plasmodium falciparum is linked to the variant surface antigen PfEMP1, which is encoded by about 60 var genes per parasite genome. Although the expression of particular variants has been associated with different clinical outcomes, little is known about var gene expression at the onset of infection. By analyzing controlled human malaria infections via quantitative...

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PMID: 27070311
DOI: 10.1371/journal.ppat.1005538

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