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Article

Epigenetic regulation of Plasmodium falciparum clonally variant gene expression during development in Anopheles gambiae.

Scientific reports - 16 Jan 2017

Gómez-Díaz Elena, Yerbanga Rakiswendé S, Lefèvre Thierry, Cohuet Anna, Rowley M Jordan, Ouedraogo Jean Bosco, Corces Victor G

Abstract excerpt

P. falciparum phenotypic plasticity is linked to the variant expression of clonal multigene families such as the var genes. We have examined changes in transcription and histone modifications that occur during sporogonic development of P. falciparum in the mosquito host. All var genes are silenced or transcribed at low levels in blood stages (gametocyte/ring) of the parasite in the human host. After infection of...

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Identifiers

PMID: 28091569
DOI: 10.1038/srep40655
PMCID: PMC5238449

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