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Repurposing of Plasmodium falciparum var genes beyond the blood stage

29 Sept 2022

Abstract excerpt

A commonly observed survival strategy in protozoan parasites is the sequential expression of clonally variant-surface antigens to avoid elimination by the host's immune response. In malaria-causing P. falciparum, the immunovariant erythrocyte-membrane protein-1 (PfEMP1) adhesin family, encoded by var genes, is responsible for both antigenic variation and cytoadherence of infected erythrocytes to the...

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PMID: 36183663
DOI: 10.1016/j.mib.2022.102207

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