Article
Rapid turnover of Plasmodium falciparum var gene transcripts and genotypes during natural non-symptomatic infections.
Revista do Instituto de Medicina Tropical de Sao Paulo - 1 Jan 2000
Wunderlich Gerhard, Alves Fabiana P, Gölnitz Uta, Tada Mauro S, Camargo Erney F P de, Pereira-da-Silva Luiz H
Abstract excerpt
The var genes of Plasmodium falciparum code for the antigenically variant erythrocyte membrane proteins 1 (PfEMP1), a major factor for cytoadherence and immune escape of the parasite. Herein, we analyzed the var gene transcript turnover in two ongoing, non-symptomatic infections at sequential time points during two weeks. The number of different circulating genomes was estimated by microsatellite analyses. In...
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