Article
Highly co-ordinated var gene expression and switching in clinical Plasmodium falciparum isolates from non-immune malaria patients.
Cellular microbiology - 1 Sept 2011
Bachmann Anna, Predehl Sabine, May Jürgen, Harder Simone, Burchard Gerd D, Gilberger Tim-Wolf, Tannich Egbert, Bruchhaus Iris
Abstract excerpt
Antigenic variation to fool the immune system is one of the molecular tricks Plasmodium uses to maintain infection in its human host. The exclusive expression of the surface-exposed PfEMP1 molecules, encoded by var genes, is the best example for this. Central questions regarding the dynamics of antigenic variation, namely the rate of switching and the regulation of var gene expression in Plasmodium falciparum,...
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