A Genome-Wide Association Study Identifies a Novel Locus for Bortezomib-Induced Peripheral Neuropathy in European Patients with Multiple Myeloma.

doi:10.1158/1078-0432.CCR-15-3163

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Article

A Genome-Wide Association Study Identifies a Novel Locus for Bortezomib-Induced Peripheral Neuropathy in European Patients with Multiple Myeloma.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2016

Magrangeas Florence, Kuiper Rowan, Avet-Loiseau Hervé, Gouraud Wilfried, Guérin-Charbonnel Catherine, Ferrer Ludovic, Aussem Alexandre, Elghazel Haytham, Suhard Jérôme, Sakissian Henri Der, Attal Michel, C Munshi Nikhil, Sonneveld Pieter, Dumontet Charles, Moreau Philippe, van Duin Mark, Campion Loïc, Minvielle Stéphane

Abstract excerpt

PURPOSE: Painful peripheral neuropathy is a frequent toxicity associated with bortezomib therapy. This study aimed to identify loci that affect susceptibility to this toxicity. EXPERIMENTAL DESIGN: A genome-wide association study (GWAS) of 370,605 SNPs was performed to identify risk variants for developing severe bortezomib-induced peripheral neuropathy (BiPN) in 469 patients with multiple myeloma who received...

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Identifiers

PMID: 27060151
DOI: 10.1158/1078-0432.CCR-15-3163
PMCID: PMC5010494

Genes

PKNOX1
CBS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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