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Article

Impact of Genetic Polymorphisms on Bortezomib-Induced Peripheral Neuropathy in Multiple Myeloma: A Systematic Review and Bioinformatics Analysis.

Asian Pacific journal of cancer prevention : APJCP - 1 Jun 2026

Sultan Nadeen S, Alhallaq Ahmed S, Alhallaq Mohammed S, Arafat Heba Mohammed, Eid Sadeen, Shaqaliah Ashraf Jaber

Abstract excerpt

BACKGROUND: Bortezomib, a 26S proteasome inhibitor, has become a cornerstone in the treatment of multiple myeloma. However, its use is limited by a common and potentially serious adverse effect, bortezomib-induced peripheral neuropathy (BIPN), which manifests in 30-60% of multiple myeloma patients primarily as a sensory, distal, axonal neuropathy, often with pain, numbness, tingling, and in some cases, motor...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 42345143
DOI: 10.31557/APJCP.2026.27.6.1967

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