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Article

Genetic Susceptibility to Bortezomib-Induced Peripheral Neuroropathy: Replication of the Reported Candidate Susceptibility Loci.

Neurochemical research - 1 Mar 2017

Campo Chiara, Da Silva Filho Miguel Inacio, Weinhold Niels, Goldschmidt Hartmut, Hemminki Kari, Merz Maximilian, Försti Asta

Abstract excerpt

The introduction of proteasome inhibitors in the treatment of multiple myeloma (MM) patients has been a therapeutic success. Peripheral neuropathy (PNP) remains one of the most frequent side-effects experienced by patients who receive these novel agents. Recent investigations on the mechanisms of PNP in patients treated with bortezomib have suggested genetic susceptibility to neurotoxicity. We used data from a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 27422265
DOI: 10.1007/s11064-016-2007-9

Genes

PNP
ABCC1
ABCC6
EDN1
PSMB4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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Genetic Susceptibility to Bortezomib-Induced Peripheral Neuroropathy: Replication of the Reported Candidate Susceptibility Loci.PMID 27422265Read ↗

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