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Article

Genetic variation associated with bortezomib-induced peripheral neuropathy.

Pharmacogenetics and genomics - 1 Mar 2011

Favis Reyna, Sun Yu, van de Velde Helgi, Broderick Erin, Levey Laura, Meyers Michael, Mulligan George, Harousseau Jean-Luc, Richardson Paul G, Ricci Deborah S

Abstract excerpt

OBJECTIVE: To develop a predictive genetic signature for the development of bortezomib-induced peripheral neuropathy (PN). METHODS: Two thousand and sixteen single-nucleotide polymorphisms (SNPs) were genotyped in 139 samples from myeloma patients treated with bortezomib-melphalan-prednisone in the VISTA phase 3 trial. Single-marker association analysis for PN onset and time/cumulative dose to PN onset using the...

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Identifiers

PMID: 21228734
DOI: 10.1097/FPC.0b013e3283436b45

Genes

CTLA4
CTSS
GJE1
PSMB1
TCF4

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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