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Bortezomib induced peripheral neuropathy and single nucleotide polymorphisms in PKNOX1

16 May 2023

Abstract excerpt

We analyzed single nucleotide polymorphisms (SNPs) in PKNOX1 (rs2839629) and in the intergenic region between PKNOX1 and CBS (rs915854) by Sanger sequencing in 88 patients with multiple myeloma treated with bortezomib. All patients (n = 13) harboring a homozygous mutation in PKNOX1 (rs2839629) also had a homozygous mutated rs915854 genotype. Homozygous mutated genotypes of rs2839629 and rs915854 were...

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PMID: 37194045
DOI: 10.1186/s40364-023-00490-9

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