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Article

Genomic Characterization of Esophageal Squamous Cell Carcinoma Reveals Critical Genes Underlying Tumorigenesis and Poor Prognosis.

American journal of human genetics - 7 Apr 2016

Qin Hai-De, Liao Xiao-Yu, Chen Yuan-Bin, Huang Shao-Yi, Xue Wen-Qiong, Li Fang-Fang, Ge Xiao-Song, Liu De-Qing, Cai Qiuyin, Long Jirong, Li Xi-Zhao, Hu Ye-Zhu, Zhang Shao-Dan, Zhang Lan-Jun, Lehrman Benjamin, Scott Alan F, Lin Dongxin, Zeng Yi-Xin, Shugart Yin Yao, Jia Wei-Hua

Abstract excerpt

The genetic mechanisms underlying the poor prognosis of esophageal squamous cell carcinoma (ESCC) are not well understood. Here, we report somatic mutations found in ESCC from sequencing 10 whole-genome and 57 whole-exome matched tumor-normal sample pairs. Among the identified genes, we characterized mutations in VANGL1 and showed that they accelerated cell growth in vitro. We also found that five other genes,...

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Identifiers

PMID: 27058444
DOI: 10.1016/j.ajhg.2016.02.021
PMCID: PMC4833434

Genes

MYBL2
FADD
VANGL1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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