Article
Whole-genome sequencing of 508 patients identifies key molecular features associated with poor prognosis in esophageal squamous cell carcinoma.
Cell research - 1 Oct 2020
Cui Yongping, Chen Hongyan, Xi Ruibin, Cui Heyang, Zhao Yahui, Xu Enwei, Yan Ting, Lu Xiaomei, Huang Furong, Kong Pengzhou, Li Yang, Zhu Xiaolin, Wang Jiawei, Zhu Wenjie, Wang Jie, Ma Yanchun, Zhou Yong, Guo Shiping, Zhang Ling, Liu Yiqian, Wang Bin, Xi Yanfeng, Sun Ruifang, Yu Xiao, Zhai Yuanfang, Wang Fang, Yang Jian, Yang Bin, Cheng Caixia, Liu Jing, Song Bin, Li Hongyi, Wang Yi, Zhang Yingchun, Cheng Xiaolong, Zhan Qimin, Li Yanhong, Liu Zhihua
Abstract excerpt
Esophageal squamous cell carcinoma (ESCC) is a poor-prognosis cancer type with limited understanding of its molecular etiology. Using 508 ESCC genomes, we identified five novel significantly mutated genes and uncovered mutational signature clusters associated with metastasis and patients' outcomes. Several functional assays implicated that NFE2L2 may act as a tumor suppressor in ESCC and that mutations in NFE2L2...
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