Article
Clustered mutations in hominid genome evolution are consistent with APOBEC3G enzymatic activity.
Genome research - 1 May 2016
Pinto Yishay, Gabay Orshay, Arbiza Leonardo, Sams Aaron J, Keinan Alon, Levanon Erez Y
Abstract excerpt
The gradual accumulation of mutations by any of a number of mutational processes is a major driving force of divergence and evolution. Here, we investigate a potentially novel mutational process that is based on the activity of members of the AID/APOBEC family of deaminases. This gene family has been recently shown to introduce-in multiple types of cancer-enzyme-induced clusters of co-occurring somatic mutations...
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