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Article

ESCRT-0 complex modulates Rbf-mutant cell survival by regulating Rhomboid endosomal trafficking and EGFR signaling.

Journal of cell science - 15 May 2016

Sheng Zhentao, Yu Lijia, Zhang Tianyi, Pei Xun, Li Xuan, Zhang Zhihua, Du Wei

Abstract excerpt

The Rb tumor suppressor is conserved in Drosophila, and its inactivation can lead to cell proliferation or death depending on the specific cellular context. Therefore, identifying genes that affect the survival of Rb-mutant cells can potentially identify novel targets for therapeutic intervention in cancer. From a genetic screen in Drosophila, we identified synthetic lethal interactions between mutations of fly...

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Share to Adaptor Proteins, Signal Transducing
Share to Adaptor Proteins, Vesicular Transport

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 27056762
DOI: 10.1242/jcs.182261
PMCID: PMC4878992

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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