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Article

Loss of Rab5 drives non-autonomous cell proliferation through TNF and Ras signaling in Drosophila.

Developmental biology - 1 Nov 2014

Takino Kyoko, Ohsawa Shizue, Igaki Tatsushi

Abstract excerpt

Deregulation of the endocytic machinery has been implicated in human cancers. However, the mechanism by which endocytic defects drive cancer development remains to be clarified. Here, we find through a genetic screen in Drosophila that loss of Rab5, a protein required for early endocytic trafficking, drives non-autonomous cell proliferation in imaginal epithelium. Our genetic data indicate that dysfunction of...

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Source

Identifiers

PMID: 25224221
DOI: 10.1016/j.ydbio.2014.09.003

Genes

TNF
EGF
EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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