Article
Comparative analysis of ESCRT-I, ESCRT-II and ESCRT-III function in Drosophila by efficient isolation of ESCRT mutants.
Journal of cell science - 15 Jul 2009
Vaccari Thomas, Rusten Tor Erik, Menut Laurent, Nezis Ioannis P, Brech Andreas, Stenmark Harald, Bilder David
Abstract excerpt
ESCRT proteins were initially isolated in yeast as a single functional set of conserved components controlling endosomal cargo sorting and multivesicular body (MVB) biogenesis. Recent work has suggested that metazoan ESCRT proteins might have more functionally diverse roles, but the limited availability of ESCRT mutants in species other than yeast has hampered a thorough analysis. Here, we used a genetic...
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