Article
The Drosophila gene hid is a direct molecular target of Ras-dependent survival signaling.
Cell - 30 Oct 1998
Bergmann A, Agapite J, McCall K, Steller H
Abstract excerpt
Extracellular growth factors are required for the survival of most animal cells. They often signal through the activation of the Ras pathway. However, the molecular mechanisms by which Ras signaling inhibits the intrinsic cell death machinery are not well understood. Here, we present evidence tha...
Topics
- Animals
- Animals, Genetically Modified
- Apoptosis
- Calcium-Calmodulin-Dependent Protein Kinases
- Cell Line
- Cell Survival
- Drosophila Proteins
- Drosophila melanogaster
- ErbB Receptors
- Extracellular Signal-Regulated MAP Kinases
- Eye
- Genes, Lethal
- Genes, Suppressor
- Insect Proteins
- Mutation
- Neuropeptides
- Peptides
- Phenotype