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Article

RAB-7 antagonizes LET-23 EGFR signaling during vulva development in Caenorhabditis elegans.

PloS one - 1 Jan 2012

Skorobogata Olga, Rocheleau Christian E

Abstract excerpt

The Rab7 GTPase regulates late endosome trafficking of the Epidermal Growth Factor Receptor (EGFR) to the lysosome for degradation. However, less is known about how Rab7 activity, functioning late in the endocytic pathway, affects EGFR signaling. Here we used Caenorhabditis elegans vulva cell fate induction, a paradigm for genetic analysis of EGFR/Receptor Tyrosine Kinase (RTK) signaling, to assess the genetic...

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Source

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Identifiers

PMID: 22558469
DOI: 10.1371/journal.pone.0036489
PMCID: PMC3340361

Genes

EGFR
EGF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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RAB-7 antagonizes LET-23 EGFR signaling during vulva development in Caenorhabditis elegans.PMID 22558469Read ↗

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The LIN-2/LIN-7/LIN-10 complex mediates basolateral membrane localization of the C. elegans EGF receptor LET-23 in vulval epithelial cells.Semantic proximity Read ↗

An In Vivo EGF Receptor Localization Screen in C. elegans Identifies the Ezrin Homolog ERM-1 as a Temporal Regulator of SignalingSemantic proximity Read ↗

Inhibition of Caenorhabditis elegans vulval induction by gap-1 and by let-23 receptor tyrosine kinase.Semantic proximity Read ↗

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LET-23 receptor localization by the cell junction protein LIN-7 during C. elegans vulval induction.Semantic proximity Read ↗

sli-3 negatively regulates the LET-23/epidermal growth factor receptor-mediated vulval induction pathway in Caenorhabditis elegans.Semantic proximity Read ↗

rab7 activity affects epidermal growth factor:epidermal growth factor receptor degradation by regulating endocytic trafficking from the late endosome.Semantic proximity Read ↗

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An RNAi screen of Rab GTPase genes in <i>C. elegans</i> reveals that somatic cells of the reproductive system depend on <i>rab-1</i> for morphogenesis but not stem cell niche maintenanceSemantic proximity Read ↗

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