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Article

The Hrs/Stam complex acts as a positive and negative regulator of RTK signaling during Drosophila development.

PloS one - 21 Apr 2010

Chanut-Delalande Hélène, Jung Alain C, Baer Magdalena M, Lin Li, Payre François, Affolter Markus

Abstract excerpt

BACKGROUND: Endocytosis is a key regulatory step of diverse signalling pathways, including receptor tyrosine kinase (RTK) signalling. Hrs and Stam constitute the ESCRT-0 complex that controls the initial selection of ubiquitinated proteins, which will subsequently be degraded in lysosomes. It has...

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Identifiers

PMID: 20422006
DOI: 10.1371/journal.pone.0010245
PMCID: PMC2858154

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20422006-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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