Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Rabex-5 ubiquitin ligase activity restricts Ras signaling to establish pathway homeostasis in Drosophila.

Current biology : CB - 10 Aug 2010

Yan Hua, Jahanshahi Maryam, Horvath Elizabeth A, Liu Hsiu-Yu, Pfleger Cathie M

Abstract excerpt

The Ras signaling pathway allows cells to translate external cues into diverse biological responses. Depending on context and the threshold reached, Ras signaling can promote growth, proliferation, differentiation, or cell survival. Failure to maintain precise control of Ras can have adverse physiological consequences. Indeed, excess Ras signaling disrupts developmental patterning and causes developmental...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Body Size
Share to Extracellular Signal-Regulated MAP Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Homeostasis

Share to raf Kinases

Share to ras Proteins

Share to Ubiquitination

Share to Wings, Animal

Source

Open in PubMed Open full text

Identifiers

PMID: 20655224
DOI: 10.1016/j.cub.2010.06.058
PMCID: PMC2938185

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Rabex-5 ubiquitin ligase activity restricts Ras signaling to establish pathway homeostasis in Drosophila.PMID 20655224Read ↗

Loss of Rab5 drives non-autonomous cell proliferation through TNF and Ras signaling in Drosophila.Semantic proximity Read ↗

Ubiquitin binding and conjugation regulate the recruitment of Rabex‐5 to early endosomesSemantic proximity Read ↗

Discs large 5, an Essential Gene in Drosophila, Regulates Egg Chamber Organization.Semantic proximity Read ↗

The deubiquitinating enzyme Usp5 regulates Notch and RTK signaling during Drosophila eye development.Semantic proximity Read ↗

Impairment of ubiquitylation by mutation in Drosophila E1 promotes both cell-autonomous and non-cell-autonomous Ras-ERK activation in vivo.Semantic proximity Read ↗

Reduced cul-5 activity causes aberrant follicular morphogenesis and germ cell loss in Drosophila oogenesis.Semantic proximity Read ↗

Control of MYC-dependent apoptotic threshold by a co-amplified ubiquitin E3 ligase UBR5Semantic proximity Read ↗

Kekkon5 is an extracellular regulator of BMP signaling.Semantic proximity Read ↗

Rho GTPase function in flies: insights from a developmental and organismal perspective.Semantic proximity Read ↗

Rab5 and Rab11 maintain hematopoietic homeostasis by restricting multiple signaling pathways in DrosophilaSemantic proximity Read ↗

Membrane protein location-dependent regulation by PI3K (III) and rabenosyn-5 in Drosophila wing cells.Semantic proximity Read ↗

The Hrs/Stam complex acts as a positive and negative regulator of RTK signaling during Drosophila development.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.