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Mutational landscapes and functional insights in oral cancer and diabetes: A comparative perspective.

Computational biology and chemistry - 1 Apr 2026

Janardan Kavya, Mondal Rosy

Abstract excerpt

BACKGROUND: Oral cancer and diabetes are complex diseases characterized by shared mechanisms such as oxidative stress, metabolic dysregulation, and mitochondrial dysfunction. Earlier reports have proposed that diabetes may influence oral cancer risk through modulation of the insulin receptor substrate 1 (IRS-1) and focal adhesion kinase (FAK) pathway, which contributes to tumour progression and invasion. However,...

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PMID: 41365177
DOI: 10.1016/j.compbiolchem.2025.108793

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