Article
Accumulation of mutations over the complete mitochondrial genome in tobacco-related oral cancer from northeast India.
Mitochondrial DNA - 1 Aug 2013
Mondal Rosy, Ghosh Sankar Kumar
Abstract excerpt
Northeast India has one of the world's highest incidences of oral cancer and 90% of them are related to tobacco. We examined the complete mitochondrial genome to determine hot spot mutations in oral cancer. The complete mitochondrial genome was sequenced using PGM™ from 10 patients matched blood and tumour tissue. Overall, 26 somatic mutations were found of which nine mutations in d-loop and 17 mutations in the...
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