Article
Somatic mitochondrial DNA mutations in oral cancer of betel quid chewers.
Annals of the New York Academy of Sciences - 1 Apr 2004
Tan Duan-Jun, Chang Julia, Chen Woan-Ling, Agress Lesley J, Yeh Kun-Tu, Wang Baotyan, Wong Lee-Jun C
Abstract excerpt
Somatic mitochondrial DNA alteration is a general phenomenon that occurs in cancerous cells. Although numerous mtDNA mutations have been identified in various tumors, the pathogenic significance of these mutations remains unclear. In order to better understand the role of mtDNA mutations in the neoplastic process of oral cancer, the occurrence of mtDNA mutations in oral squamous cell carcinomas was screened by...
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