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Article

Comprehensive genomic profiling of anal squamous cell carcinoma reveals distinct genomically defined classes.

Annals of oncology : official journal of the European Society for Medical Oncology - 1 Jul 2016

Chung J H, Sanford E, Johnson A, Klempner S J, Schrock A B, Palma N A, Erlich R L, Frampton G M, Chalmers Z R, Vergilio J, Rubinson D A, Sun J X, Chmielecki J, Yelensky R, Suh J H, Lipson D, George T J, Elvin J A, Stephens P J, Miller V A, Ross J S, Ali S M

Abstract excerpt

BACKGROUND: Squamous cell cancers of the anal canal (ASCC) are increasing in frequency and lack effective therapies for advanced disease. Although an association with human papillomavirus (HPV) has been established, little is known about the molecular characterization of ASCC. A comprehensive genomic analysis of ASCC was undertaken to identify novel genomic alterations (GAs) that will inform therapeutic choices...

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PMID: 27052656
DOI: 10.1093/annonc/mdw152

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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